Sometimes also spelled Pikamilon or Pikamilone,
this is a Russian developed nootropic. It is in essence Niacin
(vitamin B3) bonded to GABA. Studies have shown that it rapidly
crosses the blood-brain barrier, however its effects are much
greater and broader than just taking a GABA and Niacin supplement.
Picamilone increases the rate of intracranial
and cortex blood circulation and has been cited as a better vasodilator
than either Hydergine, Vinpocetine or Xanthinol
The combination acts as a mild stimulant, yet
depresses aggression. This could be the clear actions of Niacin
and GABA (after all diazepam's such as Valium® increase or enhance
the activity of GABA). But, Picamilone has a tranquilizing effect,
without a sedative effect but actually with an element of stimulatory
Picamilone is also known to have a mild reversible
MAO-A inhibition and thus indicates an anti-depressant quality
Other Russian studies with Picamilone show it
to improve patients with a mild to moderate memory impairment,
emotional, hearing and speech difficulties. Furthermore, Picamilone
has reduced migraine or headache pain and aided in alcohol withdrawal.
One study showed an improvement for patients suffering from an
eye disorder called pigmented retinal abiotrophy (PRA) after 10
Most improvements are noted quickly, often within
a week of continuous treatment, and studies show that Picamilone
has very low toxicity, with few side effects. Picamilone may be
synergistic with other nootropic drugs (such as Lucidril
and Piracetam), therefore always remember to reduce overall
dosages in order to avoid headaches, nausea and vertigo.
At high dosages, seek your physician's advice
if combining with potent vasodilators such as Ginko Biloba, Nicergoline,
Vinpocetine or Xanthinol Nicotinate).
Also, due to its mild reversible MAO-A inhibition,
at high dosages, without your physician’s advice avoid combination
with other MAO-A drugs including Deprenyl and Gerovital-H3
and general anti-depressants (such as Prozac, Paxil and Zoloft
Dosages are 50mg or 100mg once,
twice or maximum three times daily with occasional breaks.
to Anti-Aging Medicine Index