an exciting new weapon in the armory of anti-aging medicine.
It is believed that the cross-linking of the proteins that make
up the human body play a role in the human aging process. Everyone
is familiar with the effects of cross-linking reactions, because
the process causes food to turn yellow and become tough and it is
the result of oxygen coming into contact with glucose and protein.
Cross-linking is medically referred to as Glycosylation and it
may be responsible for many of the problems of old age, including
senile cataracts, thickening of the arteries, cardiac enlargement,
skin aging, some cancers and damage to the immune system. Aminoguanidine
is a potent anti-glycation inhibitor, it appears to help prevent
and possibility also break some protein cross-linking.
Animal experiments have shown aminoguanidine to prevent age-related
heart enlargement and increase the collagen of arterial walls of
aged subjects by 24-30%. Long term studies conducted in Italy, indicate
that aminoguanidine reduces the "bad" form of cholesterol
(LDL) in humans and improves blood platelet condition.
Recent human and animal studies also indicate that aminoguanidine
improves diabetic conditions and improves the survival rates and
longevity of animals. It even improves renal (kidney) condition.
Most interestingly of all, aminoguanidine may have the potential
to slow the aging process by protecting the proteins that make up
the human body. Proteins such as the skin proteins (collagen and
elastin), eye lens protein, nerve protein and kidney proteins. All
the body's proteins deteriorate with advancing age and more so in
diabetes (diabetics have 2-3 times the number of cross-linked proteins
when compared to non-diabetics and this has lead credence to the
fact that diabetes can be viewed as a form of accelerated aging).
Aminoguanidine may be able to protect us from (or slow down the
progression of) age-related cataract conditions and skin toughening
to Anti-Aging Medicine Index