Recombinant Growth Hormone is GH that is synthesized
in the lab. It is a biosynthetic hormone that is identical to
human growth hormone, but it is synthesized in the lab. Creating
an exact replicate of HGH was not an easy task.
First scientist needed to isolate HGH. Once
they achieved this step they could study the DNA make-up of the
protein. Scientist quickly realized making recombinant GH would
be no easy task since they had to accurately reproduce a 191 amino
I wish I could say it was the quest to help
mankind that lead to the invention of recombinant GH, but really
it was money! Pharmaceutical companies knew that there was big
money to be made if they could create HGH in a test tube. Scientist
from the major drug companies raced to produce the 191 amino acid
hormone in a test tube. While Genentech first claimed victory
in 1985, it was a short lived success. The recombinant GH they
made was a 190 amino acid match - they were one amino acid off
from HGH. This left the door open for Eli Lilly, who in 1986 created
a 191 amino acid hormone that was an identical match to the HGH
produced by the pituitary gland. The drug is called Humatrope
and is the most widely used recombinant growth hormone today.
IGF-1 stands for Insulin-like Growth Factor
1. IGF-1 is also known as Somatomedin-C. As important as HGH is,
it does not last long in our bloodstream. In just a few short
minutes our liver absorbs HGH and converts it into growth factors.
IGF-1 is the most important growth factor that is produced. So,
IGF-1 is a hormone just like HGH, but it is easier to measure
in the body because it stays in our bloodstream longer than HGH.
You can think of HGH as the hormone that gets the ball rolling,
but IGF-1 does most of the work.
What is a Secretagogue?
A secretagogue is an agent that stimulates secretion.
For now that is all you need to know about these agents with a
funny name, but as we move on the functions of secretagogues and
HGH enhancement will become important.
What is Homeopathy?
Homeopathy is an art of healing that is based
on the principle of similars. The philosophy behind this alternative
medicine is the idea that "like cures like." "Traditional
medicine" often incorporates this same belief. For example,
a flu shot is used to prevent the flu. The shot contains small
amounts of the flu virus. The idea being that likes cure likes.
It is important to note that Homeopathic remedies
often use very small amounts of drugs and supplements. You are
not trying to cure the problem with the active ingredients in
the homeopathic remedy, you are just trying to stimulate the body
to cure itself.
The Role of HGH in the
Good news, after reading through the boring
HGH definitions page this will seem like a thriller. In this article
we begin to explore what we know about the effect of HGH on the
What role does HGH play in the body?
Human growth hormone and IGF-1 (if you need
definitions click here) have been shown to play a significant
* Conversion of body fat to muscle mass
* Growth of all tissues
* Energy level
* Tissue repair
* Whole body healing
* Cell replacement
* Bone strength
* Brain function
* Sexual function
* Organ health and integrity
* Enzyme production
* Integrity of hair, nails, skin and vital organs
Basically, anything that goes on in your body
is in some way tied to HGH. This is why HGH is often called the
"fountain of youth". Elevated HGH levels are what makes
you feel young again.
Does your body always
The good news is that your body must always
produce HGH or you would not be able to function. The bad news
is that as you get past about 20 years old, your body produces
less and less HGH each year. By age 60 you will probably have
lost 75% of the HGH that your body produced.
If you are a numbers person, here are some average
HGH secretion levels:
* At 20 years old we average 500 micrograms/day
* At 40 years old we average 200 micrograms/day
* At 80 years old we average 25 micrograms/day
Why does the body produce
less HGH as we get older?
This is the million-dollar question. It really
ties into the bigger question - Is aging a preventable disease?
For years people have believed that as we get older our body basically
wears out. The theory went that all of our organs, tissues, muscles,
bones, etc. have a set life span and will get weaker as we age.
When someone is 40 and complains that they can't do what they
did at 20, we accepted this as the natural process of getting
Research into HGH shows that aging may
be preventable to a certain extent. Let me clarify that, I am
not saying that we will all become immortal . What I am saying
is that research indicates that our body is very capable at the
age of 40 to have the same makeup as we did at the age of 20.
Okay, I am getting a little carried away - let's get back to HGH...
It was originally believed that the pituitary
gland just didn't have the capacity to produce large amounts of
HGH as we get older. However, recent studies have shown that aging
pituitary glands are capable of producing as much HGH as young
pituitary glands, if it is adequately stimulated. This shows that
the somatotrophe cell, the cell in the pituitary gland that releases
HGH, does not "lose power" as we age.
The questions still remains, if the problem
is not with the pituitary gland, then why does HGH decrease as
we age? One theory is that the pituitary gland does not "know"
it should be producing more HGH. Our body has a feedback loop
that says when the IGF-1 levels decrease, produce more HGH. For
some unknown reason it is possible that this loop is broken and
the pituitary gland has a harder time getting the signal to produce
more HGH as we age.
Another theory is that as we get older our Somatostatin
levels increase. Somatostatin is a natural inhibitor to growth
hormone. So, as we age the somatostatin levels increase and this
leads to a decrease in HGH.
As we speak a lot of very smart people are trying
to come up with a definitive answer as to why HGH levels decrease
with age, but as of now we just have theories.
Is there any way to maintain
high HGH levels as we age?
Yes. Back on our growth hormones definitions
page we discussed the recombinant GH that is made by Eli Lilly.
A doctor can do a daily injection of this GH and it will lead
to an overall increase of growth hormone in the body. It is important
to understand that recombinant GH is only available by injection.
Human growth hormone is a 191 chain amino acid hormone that is
too delicate to be made in any oral form (pill, powder, spray,
What effect does this
increase in HGH have on the body?
This is where it gets exciting. While numerous
studies have been done on the effects of HGH injections, the most
ground breaking study was done by Dr. Rudman and published in
the New England Journal of Medicine on July 5, 1990. The journal
reported that men who had taken HGH injections had shown a 8.8
percent gain in lean body mass with a 14 percent loss in body
fat - without any change in diet or activity! It bears repeating
that there was no change in diet or exercise - and the subjects
who received HGH injections had a 8.8 percent increase in lean
If you look at all the studies that have been
done on HGH injections you get the following list of benefits:
* 8.8% increase in muscle mass on average after
six months, without exercise
* 14.4% loss of fat on average after six months, without dieting
* Higher energy levels
* Enhanced sexual performance
* Regrowth of heart, liver, spleen, kidneys and other organs that
shrink with age
* Greater cardiac output
* Superior immune function
* Increased exercise performance
* Better kidney function
* Lowered blood pressure
* Improved cholesterol profile, with higher HDL and lower LDL
* Stronger bones
* Faster wound healing
* Younger, tighter, thicker skin
* Hair regrowth
* Wrinkle removal
* Elimination of cellulite
* Sharper vision
* Mood elevation
* Increased memory retention
* Improved sleep
(* The above is taken from Grow Young with HGH
by Dr. Ronald Klatz)
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