Experiments from the Harvard laboratory of David
Sinclair, published in 2003 in the journal "Nature"
demonstrated that resveratrol significantly extends
the lifespan of the yeast Saccharomyces cerevisiae. Dr. Sinclair
then founded Sirtris Pharmaceuticals to commercialize resveratrol
or related compounds as an anti-aging drug.
Later studies showed that resveratrol
prolongs the lifespan of the worm Caenorhabditis elegans and the
fruit fly Drosophila melanogaster. In 2006, it also extended the
maximum lifespan of a short-lived fish, Nothobranchius furzeri,
by 59%, and extended its median lifespan by 56%. Also noted were
an increase in swimming performance, an increase in cognitive
performance (learning tasks), and a lack of neurofibrillary degeneration
(found in a control group). The authors observed that "resveratrol's
supplementation with food extends vertebrate lifespan and delays
motor and cognitive age-related decline could be of high relevance
for the prevention of aging-related diseases in the human population."
Later in 2006, a report in the journal Nature from Sinclair's
laboratory and the Laboratory of Experimental Gerontology at the
National Institute on Aging showed that the compound improves
health and survival of mice on a high-calorie diet.
The mechanisms of resveratrol's apparent effects
on life extension are not fully understood, but they appear to
mimic several of the biochemical effects of calorie restriction.
This seems to function by means of lipase inhibition, reducing
the absorption of fat through intestinal walls. A new report indicates
that resveratrol activates SIRT1 and PGC-1a and improve functioning
of the mitochondria.
Only the "Trans" form of the molecule
is capable of activating the mammalian SIRT1 gene in vitro; this
is also the form predominantly found in red grape skins and red
wine. Red grapes grown in some regions (such as New York state)
often have much higher concentrations of resveratrol based on
the cooler climate and the resulting increase in fungal attacks
that promote resveratrol production. However, the amount in any
wine, including Muscadine grape wines, is negligible compared
to the amount that in theory is needed for health benefits: 1–10
milligrams per liter of wine versus hundreds to thousands of milligrams/day.
Resveratrol, Cancer Prevention
Resveratrol is under extensive
investigation as a cancer chemopreventive agent.
Indeed, there are studies showing that small doses of dietary
resveratrol can reduce colon carcinogenesis in
rats and mice. One German study has already been shown to that
under special conditions, resveratrol induces apoptosis in human
fat cells. In addition, it inhibits production of cytokines which
are involved in the development of obesity-related disorders.
Helps Kill Pancreatic Cancer Cells - Researchers from New
York say that resveratrol, a substance found in red wine, can
help destroy pancreatic cancer cells and is even more effective
when combined with other treatments. Scientists at the University
of Rochester Medical Center say that the naturally occurring
antioxidant cripples the cell’s core energy source called
the mitochondria. See also: Alternative
Yeast - On the life-extension front, scientists at USC have
produced a strain of yeast that lives 10 weeks, a lifespan they
describe as being equivalent to 800 years in human terms... The
active ingredient in SIRT501 is Resveratrol, the life-extending
substance which has been identified in red wine. Resveratrol has
already been shown to ...
"Quercetin is one of the secrets of red
wine. It works in tandem with resveratrol to make it more instantly
available to tissues throughout the body," says Bill Sardi,
spokesperson for Longevinex(R), maker of a leading brand resveratrol
A recently issued press release by a competing
dietary supplement company, falsely claims quercetin inhibits
bioavailability of resveratrol. "With no scientific substantiation
for their claim, they are misleading many consumers," says
Modified Wine: Would You Buy It? - According to New Scientist
magazine, a researcher at a Chinese university has created a supervine
by adding an extra gene from a Chinese vine. The gene supposedly
triggers causes the vine to produce six times the normal amount
of the resveratrol in the grapes. Resveratrol is the anti-oxidant
linked to increased longevity and other health benefits.
Might Boost Lifespan - Would you drink wine made from genetically
engineered grapes if it had extra benefits? Such wine could be
on the menu, thanks to a grape variety six times richer than normal
in resveratrol, the compound in red wine associated with increased
longevity, decreased heart disease and a host of other benefits.
Research on Resveratrol Reveals Benefit in Curbing Insulin Resistance
- Resveratrol, an antioxidant found in red wine,
may counter type 2 diabetes and insulin resistance, according
to a new study. Insulin is a hormone that controls blood sugar.
Insulin resistance occurs when the body becomes less sensitive
to insulin. This condition can lead to type 2 diabetes. Chinese
scientists report that resveratrol curbs insulin resistance in
mice. These scientists, including Cheng Sun and Qiwei Zhai of
the Chinese Academy of Sciences in Shanghai, indicate that this
is a “valuable new strategy for treating insulin resistance
and type 2 diabetes.” If the findings apply to people, it
might be possible to create new resveratrol compounds. However,
to reach the same levels of resveratrol, it would require a significant
consumption of red wine.
Wine Component May Help To Extend Life Span - A component
found in red wine grapes has shown to extend the life span of
obese mice according to a new study. The molecule is identified
as resveratrol and it helps the obese mice to live longer on a
high calorie diet without showing any signs of diseases usually
associated with and relating to being overweight.
Pill To Fight Cancer? - They're calling it a real life Fountain
of Youth. Scientists at Sirtis Pharmaceuticals say they've created
a pill that can help fight off diseases like cancer and diabetes
and literally add years to your life.
Powder Shown to Block a Cancer Gene - A study led by Dr. Randall
Holcombe, director of clinical research at the Chao Family Comprehensive
Cancer Center at UC Irvine, found that a diet containing low doses
of freeze-dried grape powder may block the genes linked to the
development of sporadic colorectal cancer.
Clinical Study Shows Unique Resveratrol Delivery
Matrix Is Orally Bioactive - University human study the first
to demonstrate efficacy for a novel resveratrol-containing dietary
supplement. A university clinical study accepted for presentation
at the Annual Meeting of the American College of Sports Medicine,
Southeast Chapter in February, 2008 shows that Longevinex®,
a patent pending natural resveratrol delivery matrix, can exert
positive effects in relation to endurance exercise-induced markers
of physiologic stress.
in the mountains, and better yet, ... - GRAPE EXPECTATIONS:
The phytonutrient resveratrol in red grapes and
red wine counters aging the same way calorie restriction does.
Both activate a family of enzymes, sirtuins, that slow the body's
metabolic machinery and offset the damage of a high-calorie diet.
Mighty Muscadine - Could the skin of North Carolina's own
muscadine grape fight cancer? ... resveratrol,
a chemical found in muscadine skins, has been widely studied in
cancer research. According to the National Cancer Institute ,
research suggests it may inhibit the growth of or cause the death
of leukemia cells and cells of cancers of the head, neck, breast,
ovary, prostate and colon, among others. It also may be a potent
Things To Do This Week To Make You Healthy - Drinking half
a glass of red wine daily could guard against colon cancer, scientists
have announced. Or you could eat grapes every day. An ingredient
contained in the fruit, called resveratrol, blocks
the chemical pathway that helps spread colon cancer, says a team
at the University of California.
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