Anti Aging Today

Resveratrol, Anti Aging

Resveratrol, Life Extension And Anti-Aging

Experiments from the Harvard laboratory of David Sinclair, published in 2003 in the journal "Nature" demonstrated that resveratrol significantly extends the lifespan of the yeast Saccharomyces cerevisiae. Dr. Sinclair then founded Sirtris Pharmaceuticals to commercialize resveratrol or related compounds as an anti-aging drug.

Later studies showed that resveratrol prolongs the lifespan of the worm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. In 2006, it also extended the maximum lifespan of a short-lived fish, Nothobranchius furzeri, by 59%, and extended its median lifespan by 56%. Also noted were an increase in swimming performance, an increase in cognitive performance (learning tasks), and a lack of neurofibrillary degeneration (found in a control group). The authors observed that "resveratrol's supplementation with food extends vertebrate lifespan and delays motor and cognitive age-related decline could be of high relevance for the prevention of aging-related diseases in the human population." Later in 2006, a report in the journal Nature from Sinclair's laboratory and the Laboratory of Experimental Gerontology at the National Institute on Aging showed that the compound improves health and survival of mice on a high-calorie diet.

The mechanisms of resveratrol's apparent effects on life extension are not fully understood, but they appear to mimic several of the biochemical effects of calorie restriction. This seems to function by means of lipase inhibition, reducing the absorption of fat through intestinal walls. A new report indicates that resveratrol activates SIRT1 and PGC-1a and improve functioning of the mitochondria.

Only the "Trans" form of the molecule is capable of activating the mammalian SIRT1 gene in vitro; this is also the form predominantly found in red grape skins and red wine. Red grapes grown in some regions (such as New York state) often have much higher concentrations of resveratrol based on the cooler climate and the resulting increase in fungal attacks that promote resveratrol production. However, the amount in any wine, including Muscadine grape wines, is negligible compared to the amount that in theory is needed for health benefits: 1–10 milligrams per liter of wine versus hundreds to thousands of milligrams/day.

Resveratrol, Cancer Prevention

Resveratrol is under extensive investigation as a cancer chemopreventive agent. Indeed, there are studies showing that small doses of dietary resveratrol can reduce colon carcinogenesis in rats and mice. One German study has already been shown to that under special conditions, resveratrol induces apoptosis in human fat cells. In addition, it inhibits production of cytokines which are involved in the development of obesity-related disorders.

Resveratrol News

Resveratrol Helps Kill Pancreatic Cancer Cells - Researchers from New York say that resveratrol, a substance found in red wine, can help destroy pancreatic cancer cells and is even more effective when combined with other treatments. Scientists at the University of Rochester Medical Center say that the naturally occurring antioxidant cripples the cell’s core energy source called the mitochondria.
See also: Alternative Cancer Therapy

Methuselah Yeast - On the life-extension front, scientists at USC have produced a strain of yeast that lives 10 weeks, a lifespan they describe as being equivalent to 800 years in human terms... The active ingredient in SIRT501 is Resveratrol, the life-extending substance which has been identified in red wine. Resveratrol has already been shown to ...

"Quercetin is one of the secrets of red wine. It works in tandem with resveratrol to make it more instantly available to tissues throughout the body," says Bill Sardi, spokesperson for Longevinex(R), maker of a leading brand resveratrol dietary supplement.

A recently issued press release by a competing dietary supplement company, falsely claims quercetin inhibits bioavailability of resveratrol. "With no scientific substantiation for their claim, they are misleading many consumers," says Sardi.

Genetically Modified Wine: Would You Buy It? - According to New Scientist magazine, a researcher at a Chinese university has created a supervine by adding an extra gene from a Chinese vine. The gene supposedly triggers causes the vine to produce six times the normal amount of the resveratrol in the grapes. Resveratrol is the anti-oxidant linked to increased longevity and other health benefits.

Super-Wine Might Boost Lifespan - Would you drink wine made from genetically engineered grapes if it had extra benefits? Such wine could be on the menu, thanks to a grape variety six times richer than normal in resveratrol, the compound in red wine associated with increased longevity, decreased heart disease and a host of other benefits.

Can the Red Wine Molecule Actually Add Twenty Years to the Life Span of Humans? A New Study by Doctors in England Confirms High Dosages of Resveratrol are Safe - Resveratrol has become the anti-aging story of 2007 and possibly the decade. If you decide to try this so-called "Miracle Molecule" there are some things you should know first, facts and myths about resveratrol supplements.

Red Wine Resveratrol - In Quest Of An Anti-Aging Pill, 2007 In Review - Advancements toward an anti-aging pill continue to unfold, but will such a pill ever be adopted by modern medicine, and will the masses ever use it?

New Research on Resveratrol Reveals Benefit in Curbing Insulin Resistance - Resveratrol, an antioxidant found in red wine, may counter type 2 diabetes and insulin resistance, according to a new study. Insulin is a hormone that controls blood sugar. Insulin resistance occurs when the body becomes less sensitive to insulin. This condition can lead to type 2 diabetes. Chinese scientists report that resveratrol curbs insulin resistance in mice. These scientists, including Cheng Sun and Qiwei Zhai of the Chinese Academy of Sciences in Shanghai, indicate that this is a “valuable new strategy for treating insulin resistance and type 2 diabetes.” If the findings apply to people, it might be possible to create new resveratrol compounds. However, to reach the same levels of resveratrol, it would require a significant consumption of red wine.

Red Wine Component May Help To Extend Life Span - A component found in red wine grapes has shown to extend the life span of obese mice according to a new study. The molecule is identified as resveratrol and it helps the obese mice to live longer on a high calorie diet without showing any signs of diseases usually associated with and relating to being overweight.

A Pill To Fight Cancer? - They're calling it a real life Fountain of Youth. Scientists at Sirtis Pharmaceuticals say they've created a pill that can help fight off diseases like cancer and diabetes and literally add years to your life.

Grape Powder Shown to Block a Cancer Gene - A study led by Dr. Randall Holcombe, director of clinical research at the Chao Family Comprehensive Cancer Center at UC Irvine, found that a diet containing low doses of freeze-dried grape powder may block the genes linked to the development of sporadic colorectal cancer.

Pioneering Clinical Study Shows Unique Resveratrol Delivery Matrix Is Orally Bioactive - University human study the first to demonstrate efficacy for a novel resveratrol-containing dietary supplement. A university clinical study accepted for presentation at the Annual Meeting of the American College of Sports Medicine, Southeast Chapter in February, 2008 shows that Longevinex®, a patent pending natural resveratrol delivery matrix, can exert positive effects in relation to endurance exercise-induced markers of physiologic stress.

Walking in the mountains, and better yet, ... - GRAPE EXPECTATIONS: The phytonutrient resveratrol in red grapes and red wine counters aging the same way calorie restriction does. Both activate a family of enzymes, sirtuins, that slow the body's metabolic machinery and offset the damage of a high-calorie diet.

The Mighty Muscadine - Could the skin of North Carolina's own muscadine grape fight cancer? ... resveratrol, a chemical found in muscadine skins, has been widely studied in cancer research. According to the National Cancer Institute , research suggests it may inhibit the growth of or cause the death of leukemia cells and cells of cancers of the head, neck, breast, ovary, prostate and colon, among others. It also may be a potent anti-inflammatory agent.

7 Things To Do This Week To Make You Healthy - Drinking half a glass of red wine daily could guard against colon cancer, scientists have announced. Or you could eat grapes every day. An ingredient contained in the fruit, called resveratrol, blocks the chemical pathway that helps spread colon cancer, says a team at the University of California.

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